The Black Stars of Ghana will play the Bafana Bafana of South Africa in the 2021 Africa Cup of Nations qualifier match in Cape Coast on Thursday, November 14.
The match is expected to kick-off at 7pm local time.
Both teams begin their journey to the next AFCON in Cameroon after a poor performance at the 2019 edition in Egypt.
The Black Stars of Ghana exited the competition in the round of 16 while the South Africans lost to Nigeria in the quarter finals.
Black Stars coach, Kwesi Appiah is expected to hand some debutants the opportunity to play for the senior national team.
Ghana have played South Africa 13 times; 11 being competitive matches. The two African giants have drawn five times in the process. The Bafana Bafana boys have beaten the Black Stars four times and lost on three occasions.
Ghana first played South Africa in November 1994 with Bafana defeating Ghana 2-1 in the Four Nations Cup in Pretoria.
The two nations have won the AFCON four times together – South Africa won the Africa Cup of Nations for the first and only time in 1996.